Fibrosis Models - IPF
Bleomycin-induced Idiopathic Pulmonary Fibrosis (IPF)
MLM Medical Labs offers an advanced Bleomycin-induced Lung Fibrosis model, established for over a decade in basic research on pulmonary fibrosis. Our methodology employs refined oral aspiration administration, facilitating uniform disease distribution in both right and left lungs. This model serves as a reliable tool for in-depth scientific investigations, particularly in the study of idiopathic pulmonary fibrosis (IPF). Researchers can leverage this well-established model at MLM Medical Labs to gain valuable insights into the intricacies of lung injury.
Interested in the intricacies of systemic sclerosis? Through our expertise in systemic/subcutaneous bleomycin administration, we not only can study lung fibrosis but also unravel its effects on the skin. For a comprehensive exploration of our systemic sclerosis model and it’s implications, visit our dedicated systemic sclerosis page.
Standard Readouts:
- Body weight
- Clinical observations
- Histology including H&E (Ashcroft Score) and MT (Collagen Score)
Additional Readouts:
- Lung tissue cellularity
- Bronchoalveolar Lavage Fluid (BALF) cellularity
- Biomarkes including TGF-β in Bronchoalveolar Lavage Fluid (BALF) and peripheral blood
- Histology inlcuding IHC expression assessment of immune of specific markers of interest such as CD3, CD4, CD8 etc.
- qPCR analysis for gene expression
- Hydroxyproline analysis
Are you interested in a variation of a model or a new paradigm?
Our scientists are passionate about the development of new models! We often participate in opportunities for co-development and pilot programs to establish new models and reach new levels of understanding. Contact our team today!