Skip to content
  • CAREERS
  • RFP

MLM ONLINE ®

Search
MLM Medical Labs
  • Meet MLM
    • About
    • Leadership
    • Global Reach Without Compromise
    • Customers
    • Quality / Accreditations & Certifications
    • MLM News and Insights
  • Services
    • Preclinical
      • Preclinical Services Overview
      • Cell Culture Modeling
      • In-Vivo Models
    • Translational
      • Assay Development and Validation
      • Medical Device Support
      • Animal Nutritional Developmental Studies
    • Histology
      • Histopathology Services Overview
      • Histology Image Gallery
    • Central lab services
      • Central Lab Overview
      • Safety Lab Testing
      • Study Set Up
      • Sample Analysis
      • Kit Building
      • mlm online
      • Data Management
      • Global Logistics
    • MLM kit building
      • Kit Building
      • Safeguard Box
    • Biological Sample Management
      • Point of Collection Tracking
  • Analytical Overview
  • Assay Menu
  • Resources
    • Knowledge Library
    • Unit Converter
    • Histology Image Gallery
  • Contact
    • Contact Us
    • Request For Proposals
    • Subscribe
    • Locations
  • CAREERS
  • RFP

MLM ONLINE ®

Search
MLM Medical Labs
  • Meet MLM
    • About
    • Leadership
    • Global Reach Without Compromise
    • Customers
    • Quality / Accreditations & Certifications
    • MLM News and Insights
  • Services
    • Preclinical
      • Preclinical Services Overview
      • Cell Culture Modeling
      • In-Vivo Models
    • Translational
      • Assay Development and Validation
      • Medical Device Support
      • Animal Nutritional Developmental Studies
    • Histology
      • Histopathology Services Overview
      • Histology Image Gallery
    • Central lab services
      • Central Lab Overview
      • Safety Lab Testing
      • Study Set Up
      • Sample Analysis
      • Kit Building
      • mlm online
      • Data Management
      • Global Logistics
    • MLM kit building
      • Kit Building
      • Safeguard Box
    • Biological Sample Management
      • Point of Collection Tracking
  • Analytical Overview
  • Assay Menu
  • Resources
    • Knowledge Library
    • Unit Converter
    • Histology Image Gallery
  • Contact
    • Contact Us
    • Request For Proposals
    • Subscribe
    • Locations

News and Events, Scientific Publications

hidradenitis suppurativa, MLM Medical Labs, Dermatology Research

MLM Medical Labs Supports Leading Biotech Company in a Non-Interventional Hidradenitis Suppurativa (HS) Study

MLM Medical Labs – Minneapolis recently partnered with a leading biotech company on the CSL324 study of a novel, fully human anti-G-CSF receptor (G-CSFR) monoclonal antibody in the treatment of hidradenitis suppurativa (HS). 

CSL324 is being investigated as a potential treatment in the management of HS, a chronic, painful and debilitating inflammatory skin disease.

The trial was designed to assess the ability of CSL324, a granulocyte colony-stimulating factor receptor (G-CSFR) antagonist, to impact the activation and migration of neutrophils in hidradenitis suppurativa (HS) patients.

MLM Medical Labs provided all of the histology services for this study. This included pre-analysis processing of received samples, embedding (where we took care to ensure samples were properly oriented), and sectioning. We validated assays for neutrophil markers myeloperoxidase (MPO) and neutrophil elastase (NE) and then conducted study sample staining for MPO and NE as well as hematoxylin and eosin (H&E) staining. The stained slides were imaged for virtual viewing and assessments. MLM provided histopathology assessment of the HS biopsies in comparison the healthy skin, which included pathologist scoring to assess the number of cells positive for each of the neutrophil markers. Using our data, it was determined that these markers were significantly increased in the HS lesions compared to the healthy donors, suggesting that antagonist to G-CSFR, such as CSL324, would be a good candidate for HS therapy.

The abstract link from the British Journal of Medicine can be seen on PubMed HERE. 

Share this:

Facebook
Twitter
LinkedIn
All Categories
Brochures
Clinical Insights
News and Events
Press Releases
Scientific Publications
Videos

Related Posts

MLM Drs. Ben Curry and Lisa Jennings Published in the August Issue of the Journal of Thrombosis and Thrombolysis

Read now »

Vial Announces Collaborative Alliance with MLM Medical Labs

Read now »

Understanding the Importance (and Unleashing the Power) of Preclinical Study Design: MLM Medical Labs’ Dynamic Approach 

Read now »

MLM Medical Labs Launches Optimized IPF Preclinical Model, Achieving Reduced Mortality Rates

Read now »

MLM Medical Labs Introduces Newly Validated MC903 Atopic Dermatitis Model for Preclinical Research

Read now »
Subscribe to mlm newsletter

Share this:

Post navigation
← Previous Post
Next Post →

© 2023 MLM Medical Labs

  • Editorial Information
  • Privacy Policy
Subscribe to mlm newsletter
Dinosaur 90s style

MLM turns 30 this year!

Submit your favorite photo from '93 to win!