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Clinical Insights

Immune Profiling through flow cytometry at MLM Medical Labs

Accelerate Your Preclinical Research with Advanced Flow Cytometry Services

Unlock Cellular Insights to Propel Drug Discovery and Immunotherapy Development
Why Flow Cytometry Matters in Preclinical Research and Drug Discovery

Our advanced Flow Cytometry services empower researchers to gain deep insights into cellular mechanisms, evaluate drug efficacy, and ensure safety — all critical steps before advancing to clinical trials.

Flow cytometry is indispensable for revealing detailed insights into cellular mechanisms, drug efficacy, and safety—key factors that inform go/no-go decisions before clinical trials. At MLM Medical Labs, we develop customized, GLP-compliant panels that precisely align with your preclinical needs, ensuring you receive data that is directly relevant to your research goals. In addition, we offer on-site in-vivo models, enabling us to analyze your preclinical flow samples while also streamlining the process by reducing the need for multiple vendors, ensuring the integrity of your samples is preserved.

Therapeutic Application of Flow Cytometry Panels

Every disease model has distinct cellular characteristics. Our team partners with you to design and refine flow cytometry panels that address your unique requirements, providing meaningful, actionable data across a range of therapeutic areas. Some of these include:

  • Respiratory Diseases
  • Dermal Diseases
  • Metabolic Diseases
  • Fibrosis
  • Arthritis
  • Sepsis
  • Other immunology-based diseases
Flow Cytometry Applications in Preclinical Drug Discovery

At MLM, we have conducted diverse studies using Flow Cytometry, including:

Immune Cell Profiling
▪Identified/phenotyped T cells, B cells, NK cells in immuno-oncology and vaccine research.  
▪ Monitored immune checkpoint inhibitors and activation markers in early-stage therapies.

Mechanism of Action (MoA) Studies
▪ Assessed cell signaling and immune activation pathways.  
▪ Quantified cytokine production for tumor-targeting validation.

Pharmacodynamic (PD) Biomarker Analysis
▪ Tracked immune responses and cell population shifts.  
▪ Optimized dosing strategies through PD biomarker analysis.

Receptor Occupancy Studies
▪ Measured drug-receptor engagement to confirm target binding and optimize dosing.

Toxicity Screening
▪ Detected off-target effects, including cytokine release syndrome in CAR-T therapies.

Cell Therapy Quality Control
▪ Ensured viability, purity, and proper transduction of therapeutic cells (e.g., CAR-T).

Drug Delivery Monitoring
▪ These studies span areas such as Respiratory Diseases, Dermal Diseases, Metabolic Diseases, Fibrosis, Arthritis, Sepsis, and immunology-based conditions, delivering actionable preclinical data.

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Advanced Equipment

Our labs are equipped with the following advanced flow cytometry systems to meet all your analysis needs for human, and rodent samples:

BD LSR Fortessa X20
▪  A high-performance flow cytometer designed for complex, multi-parameter analysis with up to five lasers and the ability to detect 20 or more colors simultaneously

BD FACSLyric
▪ A compact, reliable system ideal for streamlined, high-throughput flow cytometry; known for its precision and consistency, it is well-suited for routine immunoassays and targeted biomarker analysis in both human and rodent samples

BD FACSLyric and BD LSR Fortessa X20 at MLM Medical Labs
Expertly  Tailored Design

At the forefront of immunological research, MLM designs our panels to provide  specific solutions for your study needs.

▪ Optimized and Customized Panel Design
▪ Custom immunophenotyping panels for human, mouse and rat models
▪ Expanded marker range beyond TBNK to capture detailed immune cell populations and functional states.
▪ Fluorophore selection tailored to flow instrument configuration.
▪ Markers distributed across lasers to minimize spillovers.
▪ Expression levels matched with appropriate fluorophores (bright for low expression, dim for high expression).
▪ Advanced techniques such as phosphoflow areavailable which provide deeper insights to cellular signaling pathways.

Moving Your Research Forward with MLM Medical Labs

Our customized flow cytometry panels in the preclinical stage provide you with precise data that can save time and resources by optimizing your therapeutic candidates before they reach clinical trials. This targeted approach not only enhances your ability to make data-driven decisions but also helps support your regulatory submissions with robust, detailed cellular data.

Our Flow Cytometry Capabilities

▪ High-throughput immune cell profiling
▪ Multiparametric analysis for complex assays
▪ Custom assay development for target-specific research
▪Expertise in monitoring cell-based therapies

Why Choose MLM Medical Labs?

▪ Global Reach: Trusted by leading biopharma companies for research collaborations.
▪ Validated Assays: Deployment-ready assays tailored for preclinical and clinical trial success.
▪ Established in-vivo Preclinical Disease Models: on site in-vivo study capabilities eliminating the need for multiple vendors for ex-vivo assessments for faster results, better sample integrity and consistent data quality
▪ Speed and Reliability: Fast turnaround with assured quality control.
▪ Scientific Expertise: Our scientists collaborate closely with sponsors to optimize protocols and maximize data quality.
▪ Success in Action

We’ve supported global clinical trials and preclinical programs across multiple therapeutic areas. Our experience includes working on CAR-T cell therapies, immune checkpoint inhibitors, and Factor XI inhibitors, ensuring precise and actionable insights at every stage.

DOWNLOAD OUR FLOW CYTOMETRY CAPABILITIES SHEET
Ask our Business Development Director
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